Zoonotic influenza viruses: antigenic and genetic characteristics and development of candidate vaccine viruses for pandemic preparedness.
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چکیده
La sélection et la mise au point de virus vaccinaux candidats représentent les premières étapes vers une production en temps utile des vaccins; mais cela n’implique pas qu’il soit recommandé d’en démarrer la fabrication. Les autorités nationales peuvent envisager d’utiliser un ou plusieurs des virus vaccinaux candidats pour la production de lots pilotes de vaccins, la réalisation d’essais cliniques et d’autres activités de préparation à une pandémie, en fonction de leur évaluation des risques et des besoins pour la santé publique.
منابع مشابه
Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness.
Zoonotic influenza viruses continue to be identified and evolve both genetically and antigenically, leading to the need for update of candidate vaccine viruses for pandemic preparedness purposes. Evaluation of the genetic and antigenic characteristics of these viruses, their relationship to existing candidate vaccine viruses, and their potential risks to public health, justify the need to selec...
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The development of representative A(H5N1) and A(H9N2) candidate influenza vaccine viruses, coordinated by the World Health Organization (WHO), remains an essential component of the overall global strategy for pandemic preparedness. Comparisons of the candidate vaccine viruses with respect to immunogenicity and their relationship to newly emerging viruses are ongoing, and will be updated periodi...
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Influenza viruses continue to be a major health threat in human and bird populations. The improvements in formulation and production level of the current influenza vaccines are not sufficient to afford complete protection. The continuous antigenic drifts and emergence of endemic and zoonotic strains make influenza vaccine planning difficult. Concern about the emergence of new influenza pandemic...
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The spread of influenza viruses in multiple bird and mammalian species is a worldwide serious threat to human and animal populations' health and raise major concern for ongoing pandemic in humans. Direct transmission of the avian viruses which have sialic acid specific receptors similar to human influenza viruses are a warning to the emergence of a new mutant strain that is likely to share mole...
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Since their reemergence in 2003, H5N1 influenza viruses have become endemic in some countries and continue to cause outbreaks in poultry and sporadic human infections. It is not known if the next influenza pandemic will be caused by H5N1 viruses or, should one occur, which of the clades of H5N1 viruses would be responsible. However, because an H5N1 pandemic is a possibility, and one with potent...
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ورودعنوان ژورنال:
- Releve epidemiologique hebdomadaire
دوره 91 42 شماره
صفحات -
تاریخ انتشار 2016